In this series of five episodes, all shot on a stage set in front of a live studio audience, the artist Jonathan Grossmalerman, a once successful painter in a serious career slump has been offered an exhibition at his dream gallery…but there’s a catch! He can’t show any of the incredibly explicit paintings that helped make his name. All that pressure would be enough to send any artist into a full-fledged creative crisis! But Grossmalerman still has to contend with the haunted Basquiat painting his girlfriend dragged home, his estranged eleven year old daughter who just moved in and a violent series of events that include but are not limited to, an assassin, a toxic romance, an inappropriate relationship, and a very angry collector.
Grossmalerman gets offered a show at his dream gallery but gets shocking news. His ex-wife has died and left him with their 11 year old daughter Tracie! And to make matters worse he has to completely change what he paints and his girlfriend Joyce just brought home a haunted Basquiat painting. Unfinished at the time of his death, Basquiat's spirit remains trapped in this world until he’s happy with the composition.
As Grosssmalerman adapts to having a haunted studio he begins receiving mysterious phone calls from an angry collector “with a voice like a snake” about a returned painting used to smuggle cocaine. Joyce seeks the help of an itinerant preacher who promises to excorsize the ghost while Neal and Elizabeth's relationship takes a dark turn and Mike, the building handyman, helps Grossmalerman get a great new painting idea. Tracie is feeling ignored.
Basquiat’s Ghost becomes really destructive and Jonathan’s dream gallery asks him to come up with better idea. Tracie befriends the Ghost of Basquiat while Neal and Elizabeth’s romance grows even more toxic. Joyce visits a shady witchdoctor and Jonathan decides to paint portraits of his closest friends. Now he just needs some friends. A plan is hatched to help Basquiat’s Ghost finish his painting. He becomes visible on account of he likes the plan.
Jonathan’s dream gallery isn’t into the new “friend” paintings either. The angry collector “with a voice like a snake!” hires a bumbling assassin to to kill Grossmalerman. Basquiat’s ghost gets depressed, ignoring Tracie who turns to Mike for emotional support while Neal and Elizabeth hit rock bottom and Jonathan has an incredibly emotionally draining epiphany which inspires a new suite of painting called “The Helping Paintings”
Basquiat’s Ghost saves Grossmalerman from the bumbling assassin. Neal breaks up with Elizabeth and gets clean in time to go face to face with the Angry Collector. Basquiat’s Ghost is dispatched to the next world when his painting is accidentally finished by the itinerant preacher and Jonathan’s dream gallery likes the new “Helping Paintings” but when Tracie tells everyone she’s moving in with Mike all hell breaks loose.